Plain Language Research Summaries
Studying the Immune and Genetic Mechanisms of JIA and RA (Dr. Daniela Ardelan)
A group of clinician researchers and scientists from the Western University Bone & Joint Institute, Dr. Daniela Ardelean (PI), Dr. Cheryle Seguin and Dr. Janet Pope (Co-PI) have enrolled the first patients with arthritis into an innovative research project that aims to re-create inflamed joints and tissues from children and adults with inflammatory arthritis. They will generate self-renewing cells called induced pluripotent stem cells from those affected and then guide these cells into becoming inflamed tissues. By modeling juvenile idiopathic and rheumatoid arthritis in laboratory, the team from London, Ontario will be able to better understand the causes of arthritis and screen new individualized therapies for those affected. This multidisciplinary research endeavor is supported by the Western University Bone and Joint Institute, Children’s Health Research Institute, Department of Pediatrics and the Academic Medical Organization of Southwestern Ontario.